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The Great Six-Syllable Dhāraṇī Sūtra is a lost Buddhist scripture, traditionally attributed to ancient Indian masters, with its specific author unknown. This sutra belongs to the esoteric dhāraṇī genre, with its core content being the six-syllable mantra, renowned for its supreme merits in dispelling calamities, invoking blessings, and purifying karmic obstacles. Historically circulated within Chinese Buddhist communities, it likely had a translation during the Tang dynasty, but was later lost due to warfare and other disturbances. As an important early esoteric text, this sutra holds a significant place within the Buddhist mantra system. Its six-syllable mantra is regarded as a precursor to the heart mantra of Avalokiteśvara (Guanyin) and profoundly influenced the formation of the six-syllable great mantra in Tibetan Buddhism. Although the original text is lost, fragments of its teachings and practices can still be glimpsed through quotations in other scriptures.